Mammalian sperm-egg recognition: does fertilin β have a major role to play?

The sperm surface antigen tMDC I (also known as cyritestin) has been proposed to play a role in sperm–egg binding in the mouse via an interaction between its disintegrin-like domain and an integrin receptor on the oolemma plasma membrane. Here we report the cloning and sequence of human tMDC I transcripts and show that they are non-functional, owing to the presence of a variety of deletions, insertions and in-frame termination codons. The absence of a tMDC I protein is further supported by the lack of immunoreactivity on Western blots of human testis and sperm extracts probed with macaque (Macaca fascicularis) and human anti-tMDC I antisera.

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Mammalian Sperm-Egg Recognition and Binding in vitro. I. Specificity of Sperm Interactions with Live and Fixed Eggs in Homologous and Heterologous Inseminations of Hamster, Mouse, and Guinea Pig Oocytes

Biology of Reproduction ◽

10.1095/biolreprod23.5.1075 ◽

1980 ◽

Vol 23 (5) ◽

pp. 1075-1085 ◽

Cited By ~ 45

Author(s):

Eli D. Schmell ◽

Bela J. Gulyas

Keyword(s):

Guinea Pig ◽

Egg Recognition ◽

Mammalian Sperm

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Faculty Opinions recommendation of Ultrastructure and lipid composition of detergent-resistant membranes derived from mammalian sperm and two types of epithelial cells.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725795147.793517857 ◽

2016 ◽

Author(s):

Bruno Stieger

Keyword(s):

Epithelial Cells ◽

Lipid Composition ◽

Mammalian Sperm ◽

Detergent Resistant Membranes

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Cationic channels have a key role in mammalian sperm cryotolerance

Cryobiology ◽

10.1016/j.cryobiol.2020.10.158 ◽

2020 ◽

Vol 97 ◽

pp. 290

Author(s):

Ariadna Delgado-Bermúdez ◽

Marc Llavanera ◽

Júlia Batlle ◽

Sergi Bonet ◽

Marc Yeste ◽

...

Keyword(s):

Mammalian Sperm ◽

Cationic Channels

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Incidence of chromosome aberrations in mammalian sperm stained with Hoechst 33342 and UV-laser irradiated during flow sorting

Mutation Research/Environmental Mutagenesis and Related Subjects ◽

10.1016/0165-1161(87)90011-2 ◽

1987 ◽

Vol 182 (5) ◽

pp. 265-274 ◽

Cited By ~ 39

Author(s):

B.L. Libbus ◽

S.D. Perreault ◽

L.A. Johnson ◽

D. Pinkel

Keyword(s):

Chromosome Aberrations ◽

Uv Laser ◽

Hoechst 33342 ◽

Mammalian Sperm ◽

Flow Sorting

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Partially irreversible cold-induced lipid phase transitions in mammalian sperm plasma membrane domains: Freeze-fracture study

Journal of Experimental Zoology ◽

10.1002/jez.1402300316 ◽

1984 ◽

Vol 230 (3) ◽

pp. 473-483 ◽

Cited By ~ 87

Author(s):

W. V. Holt ◽

R. D. North

Keyword(s):

Plasma Membrane ◽

Phase Transitions ◽

Freeze Fracture ◽

Lipid Phase ◽

Membrane Domains ◽

Lipid Phase Transitions ◽

Mammalian Sperm ◽

Sperm Plasma Membrane ◽

Fracture Study ◽

Plasma Membrane Domains

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Ionic control of sperm function

Reproduction Fertility and Development ◽

10.1071/rd9950905 ◽

1995 ◽

Vol 7 (4) ◽

pp. 905 ◽

Cited By ~ 38

Author(s):

LR Fraser

Keyword(s):

Ionic Composition ◽

Ion Fluxes ◽

Sperm Function ◽

Considerable Evidence ◽

Functional Potential ◽

Mammalian Sperm ◽

Acrosomal Exocytosis ◽

Extracellular Environment

Successful sperm function leads to fertilization. It is dependent on the extracellular environment, especially the array and concentration of various ions. Considerable evidence indicates that this is because of consequent effects on the intracellular ionic composition. Although both cations and anions undoubtedly play a role in a modulating sperm function, most of the evidence currently available concerns cations. Therefore, this review will concentrate on cations, focussing on Ca2+, Na+, K+ and H+. Their requirements for successful capacitation (mammalian sperm) and acrosomal exocytosis (both invertebrate and mammalian sperm) will be considered. In particular, the mechanisms which may control ion fluxes, leading to changes in the intracellular ionic composition and subsequently to changes in sperm functional potential, will be addressed.

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